A study of the metabolism of fibrinogen after surgical operations.

نویسنده

  • J A Hickman
چکیده

1. The turnover of fibrinogen was studied in twenty-eight patients after moderate and major surgical operations and in a contrast group of thirteen patients suffering from miscellaneous chronic disorders. 2. After operation the mean biological half-life of fibrinogen was 60·1 h (SD 16,4) and the mean plasma loss of fibrinogen was 40·1% (SD 12,6) of the intravascular fibrinogen pool each 24 h. In the contrast group, respective values of96·2 h (SD 13,1) and 22'5% (SD 2,0) were obtained, which are in agreement with published values for the normal catabolism of fibrinogen. 3. When the post-operative increase in the plasma fibrinogen pool was taken into account, a massive increase in the absolute plasma loss of fibrinogen was observed with values approaching those reported for albumin turnover. 4. Possible sites ofloss and the relevance of this investigation to the detection ofdisseminated intravascular coagulation and venous thrombosis are discussed.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Unplanned Operations and Adverse Events after Surgery for Diaphyseal Fracture of the Clavicle

Background: We used a database of patients treated at three hospitals to study the primary null hypothesis that thereare no factors associated with unplanned reoperations or adverse events after surgical repair for diaphyseal claviclefracture. Additionally we addressed the following secondary study questions: 1. What is the prevalence of unplannedreoperations or adverse events...

متن کامل

اثر تمرین مقاومتی برسطح سرمی پروتئین واکنشگرC و فیبرینوژن در مردان معتاد به مواد مخدر

Objective: Addiction to narcotic drugs is associated with cardiovascular diseases; and increased levels of biomarkers, such as C-reactive protein and fibrinogen are independently correlated with the risk of cardiovascular diseases. Therefore, this study aimed to investigate the effects of 8 weeks of resistance training on C-reactive protein and fibrinogen levels in drug addicted men. Method: In...

متن کامل

Evaluation of fibrinogen and lipoprotein(a) levels in athlete and non-athlete disabled veteran men

Background: Fibrinogen and lipoprotein(a) [Lp(a)] are two cardiovascular risk factors that increase risk of atherosclerosis through inflammation and coagulation mechanisms. The aim of this study was to compare the levels of mentioned factors between athlete and non-athlete disabled veterans. Materials and methods: subjects of this study were 16 male, non-chemical warfare victim, disabled veter...

متن کامل

Changes in fibrinogen levels, plasma viscosity and insulin resistance after 4 weeks of combined sit-up and walking training

Introduction: Reports concerning the association of physical activity with markers of inflammation, coagulation, and fibrinolysis are ambiguous. The aim of this study was to assess the effect of 4 weeks of combined decomposedsit-up and walking training with two different volumes onfibrinogen, plasma viscosity and insulin resistance index (HOMA-IR) in college, young men. Methods: In this semi...

متن کامل

The effect supplementation of garlic-lemon and aerobic exercise on serum levels of CRP and fibrinogen in men overweight

Background and objective: The development of cardiovascular diseases and mortality caused this study to evaluate the effect of 6 weeks of supplemental diet and aerobic exercise on plasma levels of CRP and fibrinogen in overweight men. Method: 32 non-athletic overweight men from Qom University with a mean age of 31 ± 1.38 years, and body mass index 31.19 ± 4.18 kg / m2, were randomly assigned to...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Clinical science

دوره 41 2  شماره 

صفحات  -

تاریخ انتشار 1971